What is Disease X?

Experts fear Chinese poultry flu could
mutate into mystery disease that sparks worldwide pandemic

In Depth

This year’s global strategy plan is the first to feature an as-yet
unknown pathogen, Disease X, which may not come from an identified
source.

So should we be worried?

What is Disease X?

The WHO plan lists eight “priority diseases” that require
immediate attention based on epidemic potential or lack of
sufficient countermeasures or vaccines. The list
includes Ebola and Zika, as well as Disease X.

According to the specialised UN agency’s definition, Disease X
does not exist, but instead “represents the knowledge that a
serious international epidemic could be caused by a pathogen
currently unknown to cause human disease, and so the R&D
[research and development] Blueprint explicitly seeks to enable
cross-cutting R&D preparedness that is also relevant for an
unknown Disease X as far as possible”.

Experts say Disease X could be a mutation of an already known
disease, such as influenza, which means its composition and
effectiveness are near impossible to predict, the Daily Express reports.

Disease X “could also be deliberately developed and spread by
humans”, the newspaper says, adding that “it is understood 16
countries including the United States, have had or are suspected of
having biological weapons programmes”.

Dr Anthony Fauci, director of the US National Institute of
Allergy and Infectious Diseases, said: “As experience has taught
us, more often than not the thing that is going to hit us is
something that we did not anticipate. Just the way we didn’t
anticipate Zika, we didn’t think there would be an Ebola that would
hit cities.”

As such, “X” stands for unexpected, he explained.

When might it hit?

There is no way of knowing when Disease X might hit, what it
might look like, or how how we might tackle it, so speed and
preparation are key to staving off the threat.

CNN says that “when confronted with the
unknown, the WHO recognises that it must ‘nimbly move’ and that
this involves creating platform technologies”.

Scientists develop customisable recipes for creating vaccines.
When an outbreak happens, they can then sequence the unique
genetics of the virus causing the disease, and plug the correct
sequence into the already developed platform to create a new
vaccine.

Could the H7N9 avian flu virus be Disease X?

The Daily Telegraph reports that scientists
across the world are on high alert for a type of influenza
currently circulating among poultry in China. Known as H7N9, the
pathogen “could prove as destructive as the 1918 Spanish flu, which
killed between 50 and 100 million people a century ago”, says the
newspaper.

Professor Jonathan Van-Tam, deputy chief medical officer for
England with special responsibility for emergency preparedness and
pandemic planning, told the Telegraph that the UK government was
“gathering as much intelligence on the H7N9 virus as possible –
looking at its geographic spread, the number of human cases and any
changes in its genetic structure”.

Van-Tam said: “[H7N9] is an example of another virus which has
proven its ability to transmit from birds to humans. It’s
possible that it could be the cause of the next pandemic.”

In China, the deadly pathogen has killed 623 of the 1,625 people
who have been infected so far, according to The Sun. That equates to a mortality rate of
38%. However, the virus cannot yet be transmitted between
humans.